HMGB1-mediated enhancement of glycolysis activates hepatic stellate cells by inhibiting ferroptosis in alcoholic hepatic fibrosis
In summary, HMGB1 promoted the metabolism of HSCs towards glycolysis to inhibit ferroptosis, which eventually led to the activation of HSCs and the progression of AHF.
Authors
- Sulan Yu
- Yangyang Li
- Qing Wang
- Zhaohui Liao
- Haiyu Yan
- Jianhua Wu
- Zhengyuan Xie
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Provincial Cancer Hospital (CN)
- Second Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1186/s13287-026-04970-1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00