Human 3D Cardiac Microtissue Model to Investigate Aldosterone-Induced Fibrosis and Electrical Dysfunction
3D hMT organoids offer a relevant in vitro model to study aldosterone-mediated cardiac effects. Aldosterone directly induces fibrosis and prolongation of the QT interval in this model, which may partially explain the increase of cardiovascular risk in patients with primary aldosteronism and underscores the benefit of mineralocorticoid receptor antagonist therapy.
Authors
- Giorgia Senesi (ORCID: https://orcid.org/0009-0001-0099-9403)
- Paolo Mulatero (ORCID: https://orcid.org/0000-0002-5480-1116)
- F. D’Ascenzo
- Silvia Monticone (ORCID: https://orcid.org/0000-0002-7322-2005)
- Claudia Altomare (ORCID: https://orcid.org/0000-0001-8743-9080)
- Fabrizio Buffolo (ORCID: https://orcid.org/0000-0001-9363-0199)
- Lucio Barile
- Carolina Balbi
- Jacopo Burrello
Institutions
- Ente Ospedaliero Cantonale (CH)
- Molecular Partners (Switzerland) (CH)
- Kantonsspital Baden (CH)
- Department of Medical Sciences (BY)
- University of Turin (IT)
Publication Details
- Journal
- Hypertension
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25686
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00