Efficacy and Safety of Procalcitonin-guided Antibiotic Therapy versus Standard of Care for Sepsis: A Systematic Review and Meta-analysis
PCT-guided therapy was associated with shorter antibiotic treatment duration, though substantial heterogeneity was observed, while mortality outcomes were comparable between groups. Standardized PCT-based protocols are needed to improve consistency and clinical applicability.
Authors
- Hamza Khan (ORCID: https://orcid.org/0009-0000-0284-6382)
- Yasir Saleem (ORCID: https://orcid.org/0000-0002-2791-5177)
- Muhammad Hamza Khan (ORCID: https://orcid.org/0000-0001-8279-5430)
- G Riffat
- Md. Imtiaz Khalil Ullah
- Muhammad Khalid Afridi (ORCID: https://orcid.org/0009-0006-1009-4372)
- Farhan Ali
- Mohammad Ebad Ur Rehman
- Hafsa Arshad Azam Raja
- Khizar Yasin
- Areej Saeed
- Fatima Asad
- Iqra Bismil
- Hanifa Sardar
- Muhammad Uzair
Publication Details
- Journal
- Medical Principles and Practice
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1159/000551475
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00