A COMPARATIVE CLINICAL STUDY OF EFFICACY OF RASNADYA GUGGULU AND SHIRASHULADIVAJRA RASA VATI IN THE MANAGEMENT OF ARDHAVABHEDAKA W.S.R. TO MIGRAINE

Background: Ardhavabhedaka, a Vata-pradhana Shiroroga described in Ayurveda, closely resembles migraine and is characterized by recurrent unilateral headache with associated symptoms such as nausea, vomiting, and aura. Conventional treatments provide symptomatic relief but often have adverse effects, highlighting the need for safer Ayurvedic alternatives. Aim: To evaluate and compare the efficacy of Rasnadyaguggulu and Shirashuladivajra Rasa Vati in the management of Ardhavabhedaka (migraine). Materials and Methods: A prospective comparative clinical study was conducted on 40 patients of Ardhavabhedaka, randomly divided into two groups. Group A received Rasnadyaguggulu 500 mg twice daily with Ushna Jala, and Group B received Shirashuladivajra Rasa Vati 1 g twice daily with honey for 30 days. Assessment was done using headache severity, frequency, duration, associated symptoms, and MIDAS score. Statistical analysis was performed using paired and unpaired t-tests. Results: Both groups showed significant improvement. Rasnadyaguggulu showed greater improvement in headache severity (62.96%), duration (55.66%), vomiting (78.12%) and MIDAS score (63.63%), while Shirashuladivajra Rasa Vati showed marked reduction in headache frequency (88.8%). Overall improvement was higher in Group A (54.22%) than Group B (45.72%). Conclusion: Both formulations are effective in Ardhavabhedaka, but Rasnadyaguggulu showed comparatively better clinical efficacy in reducing headache severity, duration and associated symptoms.