Ameliorative effects of <i>Saussurea lappa</i> against hypertension and anxiety in animal models

Objectives: The aim of the following study was to perform a comparative analysis examining the impact of Saussurea lappa on both anxiety and hypertension activities. Materials and Methods: The S. lappa plant sample was collected and filtered to obtain the plant root extract by means of a Soxhlet apparatus, and was concentrated out by the assistance of rotary evaporator. Further, phytochemical screening was conducted, which helped to choose the solvent for the extract. For validating and evaluating the parameters of anxiety, for experimental animals, 24 Swiss albino mice (20–40 g) of either sex were chosen, and the elevated plus maze apparatus was used. For validating and evaluating the parameters of hypertension, for experimental animals, 24 Wistar albino rats (150-200g) of either sex and a BIOPAC apparatus was used. Results: The research resulted in histopathological, statistical and graphical data of anxiolytic and anti-hypertensive effects in the respective experimental specimen animals, that is, Swiss albino mice and Wistar albino rats. Conclusion: This research concludes and highlights the anxiolytic and anti-hypertensive potential of S. lappa root extracts, attributed to their rich phytochemical composition. Key bioactive compounds, including phenolics and flavonoids, contribute to reducing anxiety and lowering blood pressure. These findings support S. lappa as a promising natural therapy for anxiety and hypertension, warranting further research to confirm its efficacy and mechanisms.