Probiotic Lactobacillus rhamnosus mitigates PBC-like features in Mcpip1-deficient mice via modulation of gut-liver crosstalk

Probiotic intervention with Lbr represents a feasible strategy to attenuate fibrotic progression in a mouse model of autoimmune cholestatic disease by modulation of the gut-microbiome-immune crosstalk.

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Publication Details

Journal
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Published
2026-03-16
DOI
https://doi.org/10.1016/j.bbadis.2026.168216
Primary Topic
Drug Transport and Resistance Mechanisms
Type
article
Field-Weighted Citation Impact
0.00
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article

Probiotic Lactobacillus rhamnosus mitigates PBC-like features in Mcpip1-deficient mice via modulation of gut-liver crosstalk

Marcin Krawczyk, Jacqueline Rehner, Magdalena Pilarczyk-Żurek, Jolanta Jura et al.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Drug Transport and Resistance Mechanisms
article

Probiotic Lactobacillus rhamnosus mitigates PBC-like features in Mcpip1-deficient mice via modulation of gut-liver crosstalk

Marcin Krawczyk, Jacqueline Rehner, Magdalena Pilarczyk-Żurek, Jolanta Jura, Katarzyna Trzos, Anastasiia Koval, Guillem Ylla, Jerzy Kotlinowski, Gabriela Machaj, Joanna Ewa Koziel, Marcin Bednarek, S.C. Becker, Tomasz Hutsch, Szymon Surma, Md Mobashir Rahman, Bahtiyar Yilmaz, Leidy-Alejandra G Molano, Maximilian Olaf Förster, Danuta Śmierciak, Andreas Keller
article en

Abstract

Probiotic intervention with Lbr represents a feasible strategy to attenuate fibrotic progression in a mouse model of autoimmune cholestatic disease by modulation of the gut-microbiome-immune crosstalk.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseVol. 1872(5)
University of Bern (CH), Jagiellonian University (PL), Bern University of Applied Sciences (CH), Warsaw University of Life Sciences (PL), Medical University of Warsaw (PL), University Hospital of Bern (CH), Institute of Medical Microbiology and Hygiene (DE), Helmholtz Institute for Pharmaceutical Research Saarland (DE), Saarland University (DE)
Zero hunger
Openalex Percentile: Top 21%
Drug Transport and Resistance Mechanisms
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