Association Between Maternal Infection During Pregnancy and the Risk of Childhood Acute Lymphoblastic Leukemia in Offspring: A Systematic Review and Meta‐Analysis

Maternal infections during pregnancy, particularly influenza, are associated with an increased risk of childhood ALL, and borderline associations were observed for EBV and respiratory infections. The observed risk from genitourinary infections may have come from confounding. These findings emphasize the clinical importance of influenza prevention and the timely management of prenatal infections.

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Publication Details

Journal
Pediatric Blood & Cancer
Published
2026-03-15
DOI
https://doi.org/10.1002/1545-5017.70222
Primary Topic
Acute Lymphoblastic Leukemia research
Type
article
Field-Weighted Citation Impact
0.00
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article

Association Between Maternal Infection During Pregnancy and the Risk of Childhood Acute Lymphoblastic Leukemia in Offspring: A Systematic Review and Meta‐Analysis

Weixia Yu, Hao Wang, Minghong Liu, Maggie Chen et al.
Pediatric Blood & Cancer
Acute Lymphoblastic Leukemia research
article

Association Between Maternal Infection During Pregnancy and the Risk of Childhood Acute Lymphoblastic Leukemia in Offspring: A Systematic Review and Meta‐Analysis

Weixia Yu, Hao Wang, Minghong Liu, Maggie Chen, Jianzheng Cai, Shiping Wang
article en

Abstract

Maternal infections during pregnancy, particularly influenza, are associated with an increased risk of childhood ALL, and borderline associations were observed for EBV and respiratory infections. The observed risk from genitourinary infections may have come from confounding. These findings emphasize the clinical importance of influenza prevention and the timely management of prenatal infections.

Pediatric Blood & Cancer
Soochow University (CN), First Affiliated Hospital of Soochow University (CN)
Good health and well-being
Openalex Percentile: Top 25%
Acute Lymphoblastic Leukemia research
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