Bifidobacterium breve inhibits colorectal cancer via extracellular vesicles containing formate acetyltransferase
B. breve secretes pflB-loaded EVs that reshape the intestinal micro-ecology, activate CD8⁺ CTL/NK anti-tumor immunity, directly induce mitochondrial apoptosis in malignant cells, and enhance the effects of immune checkpoint blockers to overcome drug resistance, offering a precision "probiotic-EVs-active protein" triadic intervention strategy for CRC.
Authors
- Yaning Xu
- Hao Chen (ORCID: https://orcid.org/0000-0002-0652-3297)
- Yue Luo (ORCID: https://orcid.org/0000-0002-1931-2181)
- Yanjun Hong
- Yuefeng Zhang (ORCID: https://orcid.org/0000-0002-3364-7762)
- Xiaohan Li (ORCID: https://orcid.org/0000-0001-9311-6253)
- R. Zhao
- Hao Li
- Qian Zhang
- Zhiyong Xie
- Xinyu Bai
- Saixuan Zhang
Institutions
- Shenzhen University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1186/s12951-026-04275-8
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00