Visible-Light-Induced Bi <sub>2</sub> O <sub>3</sub> Catalysis toward 2-fold <i>gem</i> -Difluoroalkylation of Quinoxalinones
A 2-fold <i>gem</i>-difluoroalkylation of quinoxalinones with exclusive C3 and C5 position selectivity is reported using inexpensive semiconductor Bi<sub>2</sub>O<sub>3</sub> as a photocatalyst under visible-light irradiation. The protocol is distinguished by its unconventional selectivity and exhibits broad substrate generality with high yields. Synthetic utilities were demonstrated through reaction scale-up and downstream product diversification, enabling access to broader scaffold diversity.
Authors
- Karunamayee Mondal
- Karthikeyan Jayabalan
- Mahima Pilania
- Mahiuddin Baidya
Institutions
- Indian Institute of Technology Madras (IN)
- Sathyabama Institute of Science and Technology (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1021/acs.orglett.6c00531
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00