Comparative efficacy and safety of rituximab versus cyclophosphamide with steroids in primary membranous nephropathy: a systematic review and meta-analysis
The current limited evidence suggests that RTX treatment has comparable efficacy and safety to cyclophosphamide with steroids in PMN patients at moderate risk or high risk. Further large-scale, longer follow-up, well-designed RCTs on head-to-head comparisons of the safety and efficacy of rituximab versus cyclophosphamide with steroids are urgently needed.
Authors
- Fangjiao Huang
- Zhuguang Lu
- Maorong Liu
- Peiyu Wu (ORCID: https://orcid.org/0009-0008-3172-2803)
- Yanlei Li (ORCID: https://orcid.org/0000-0003-3246-5753)
- Yifeng Xie (ORCID: https://orcid.org/0000-0001-9932-3472)
- Chenxin Fu
- Yanfang Li
Institutions
- The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- BMC Nephrology
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1186/s12882-026-04895-0
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00