An immunoregenerative approach to mitigate post-traumatic osteoarthritis after intra-articular fracture
This study suggests that KGN and KA9 may offer some protection against PTOA by influencing cartilage and subchondral bone health, and that the combination with ANR shows potential for enhanced effects. However, the results were mixed, with no treatment group consistently demonstrating positive improvements across all outcomes. The complexity of developing a novel immunoregenerative therapy for PTOA is highlighted by the variability in treatment response.
Authors
- Stephen M. Goldman (ORCID: https://orcid.org/0000-0002-2244-1443)
- Jorge B. Edwards
- M. Valerio
- Christopher L. Dearth (ORCID: https://orcid.org/0000-0003-3701-0950)
- Jessica M. Motherwell (ORCID: https://orcid.org/0000-0003-2752-3832)
- Benjamin K. Potter (ORCID: https://orcid.org/0000-0002-8771-0317)
- Andrew Clark (ORCID: https://orcid.org/0000-0003-1273-9630)
Institutions
- Henry M. Jackson Foundation (US)
- Uniformed Services University of the Health Sciences (US)
- Defense Health Agency (US)
- Walter Reed National Military Medical Center (US)
Publication Details
- Journal
- Bone and Joint Research
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1302/2046-3758.153.bjr-2024-0223.r3
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00