Phenotypic and genotypic characterization of Plasmodium falciparum field isolates lacking pfhrp2 gene
P. falciparum Peruvian field isolates with pfhrp2 positive pattern showed cytoadherence to Chondroitin sulfate A protein (R-, CS + , Hu-) or positive characteristics for rosetting (R + , CS-, Hu-); pfhrp2 negative parasites showed cytoadherence to HUVEC cells (R-, CS-, Hu +). In this small set of Peruvian field isolates, a clear cytoadherence and resolution profile was observed for the different pfhrp2 patterns. These findings should be interpreted as preliminary and require further verification in larger isolated panels.
Authors
- Dionicia Gamboa (ORCID: https://orcid.org/0000-0002-1420-7729)
- Joseph Michael Vinetz (ORCID: https://orcid.org/0000-0001-8344-2004)
- Elizabeth Villasis (ORCID: https://orcid.org/0000-0002-6824-2239)
- Jorge Bendezú (ORCID: https://orcid.org/0000-0001-7102-3144)
- Paola Larrauri-Aguilar (ORCID: https://orcid.org/0009-0003-1790-8437)
- Ronald Bautista
Institutions
- Pontificia Universidad Católica de Chile (CL)
- Universidad Peruana Cayetano Heredia (PE)
- Universidad Privada San Juan Bautista (PE)
- Yale University (US)
- Private University of the North (PE)
Publication Details
- Journal
- Malaria Journal
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1186/s12936-026-05860-w
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00