Enhanced Mitochondrial Mrs2-Mg <sup>2+</sup> Signaling Drives Mitochondrial Dysfunction in Pulmonary Arterial Hypertension Rats
Aberrant Mrs2-mediated <sub>m</sub>Mg<sup>2+</sup> signaling disrupts global ionic and metabolic homeostasis, driving mitochondrial dysfunction and pathogenic remodeling in PAH. Targeting the Mrs2-centered ionic-metabolic-dynamic axis may represent a potential therapeutic approach that warrants further investigation to interrupt PAH progression.
Authors
- Qin-Ye Chen
- Da‐Cen Lin (ORCID: https://orcid.org/0000-0001-9222-3719)
- Xiao-ling Zhuang
- Yi-Chen Lin (ORCID: https://orcid.org/0009-0001-5663-7364)
- Lan Liu (ORCID: https://orcid.org/0000-0001-8139-7246)
- Long-Xin Gui
- Mo-Jun Lin
- Yan Yan
- Ruo-Nan Chen
- Xue-Qin Weng
- James S.K. Sham
Institutions
- Fujian Medical University (CN)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Hypertension
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1161/hypertensionaha.126.25866
- Primary Topic
- Magnesium in Health and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00