Establishment of CSUASOi014-A, an induced pluripotent stem cell line from blood-derived cells of a Chinese patient carrying PRPF31 gene mutation
Retinitis pigmentosa (RP) is a group of inherited retinal degenerative disorders characterized by progressive visual dysfunction. In this study, we generated an induced pluripotent stem cell (iPSC) line, CSUASOi014-A, from peripheral blood cells of a 40-year-old Chinese female patient clinically diagnosed with RP. Peripheral blood mononuclear cells were isolated and reprogrammed using an integration-free Sendai virus system. The established iPSC line harbors a heterozygous PRPF31 c.528-39_531del mutation. CSUASOi014-A provides a patient-specific cellular resource for studying the pathogenic mechanisms underlying PRPF31-associated RP.
Authors
- Xihao Sun (ORCID: https://orcid.org/0000-0002-3470-2006)
- Hang Chen (ORCID: https://orcid.org/0000-0002-6356-3930)
- Wenwei Li
- Jiansu Chen
- Chengcheng Ding
- Chunwen Duan
- Yuqin Liang
- Yuan Liang
- Jianing Gu
- Zekai Cui
- Yuexi Chen
Institutions
- Central South University (CN)
- He Eye Hospital (CN)
- Shandong Eye Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1016/j.scr.2026.103965
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.00