Modular and Practical Synthesis of Primary Benzyl Boronic Esters from Aryl Iodides via One-Carbon Homologation

Herein, we report a one-carbon homologation strategy for the synthesis of primary benzyl boronic acid pinacol esters from aryl iodides and a chloromethyl boron reagent. This method provides efficient access to a broad range of benzyl boronic esters with clean reaction profiles, accommodates diverse functional groups and heterocycles, and enables gram-scale synthesis as well as versatile downstream transformations.