5α-dihydrotestosterone upregulates interferon signaling and limits osteoclast differentiation during inflammatory state
In summary, androgen targets OCPs and limits their differentiation into osteoclasts. In myeloid populations, DHT treatment results in differential expression of interferon-related processes and genes and alters the trajectory of cells, potentially regulating osteoclastogenesis.
Authors
- Homaira Rahimi (ORCID: https://orcid.org/0000-0003-4028-7723)
- Kiana L. Chen (ORCID: https://orcid.org/0000-0002-6691-5209)
- Chia‐Lung Wu (ORCID: https://orcid.org/0000-0001-9598-7036)
- Michael Christof (ORCID: https://orcid.org/0009-0000-0840-9095)
- Gulzada Kulzhanova
Institutions
- University of Rochester Medical Center (US)
Publication Details
- Journal
- Connective Tissue Research
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1080/03008207.2026.2642775
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00