SPP1high fibrogenic macrophages mediate protective fibrotic remodeling and promote vascular stability in hypertension-associated aortic dissection
A TGF-β1-SPP1 axis drives the emergence of SPP1<sup>high</sup> fibrogenic macrophages that support structural stabilization of the dissected aorta. Targeting this reparative myeloid program may offer a mechanistically informed therapeutic strategy for acute aortic syndromes.
Authors
- Xiumeng Hua (ORCID: https://orcid.org/0009-0006-5424-8812)
- Fei Dong (ORCID: https://orcid.org/0000-0001-9040-2887)
- Xi Yang (ORCID: https://orcid.org/0000-0001-6125-7641)
- Weiteng Wang
- Dongxing Zhu (ORCID: https://orcid.org/0000-0001-5419-438X)
- Jiangping Song (ORCID: https://orcid.org/0000-0002-9782-3323)
- Yu Gu (ORCID: https://orcid.org/0000-0001-8295-2141)
- Zhe Sun (ORCID: https://orcid.org/0000-0002-4224-9811)
- Yijing Li (ORCID: https://orcid.org/0000-0003-3479-6193)
- Yi Zhao (ORCID: https://orcid.org/0000-0003-4766-5934)
- Yifan Wang (ORCID: https://orcid.org/0009-0005-3673-9995)
- Hui Zhao (ORCID: https://orcid.org/0000-0003-2659-5180)
- Hao Cui (ORCID: https://orcid.org/0000-0003-2319-8980)
- Xiao Chen
- Hang Zhang
- Peiyuan Li
- Xiaodong Fu
- Han Mo
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Kunming Medical University (CN)
- Peking Union Medical College Hospital (CN)
- Fuwai Yunnan Cardiovascular Hospital (CN)
- Fu Wai Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1186/s12916-026-04798-9
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00