Oncostatin-M ligand-based CAR-T therapy displays robust anti-tumor activity against osteosarcoma
Human ligand-based OSM CAR-T cells displayed anti-tumor effects against multiple osteosarcoma cell lines and patient samples. These effects were demonstrated in vitro, in xenograft models, and against a model simulating metastatic disease. Overall, this data supports the continued study of OSM-CAR-T cells as a new therapeutic avenue for osteosarcoma.
Authors
- Sung Hee Choi (ORCID: https://orcid.org/0000-0003-0740-8116)
- Irina Pateva
- Gary K. Schwartz (ORCID: https://orcid.org/0000-0003-1813-5061)
- Masahiro Hitomi (ORCID: https://orcid.org/0000-0002-0937-6640)
- Claire E. Fritz (ORCID: https://orcid.org/0000-0001-7074-2323)
- Zachary D. C. Burke (ORCID: https://orcid.org/0000-0001-9601-0956)
- Alex Y. Huang (ORCID: https://orcid.org/0000-0002-5701-4521)
- Saada Eid
- Jay Myers (ORCID: https://orcid.org/0000-0003-2574-0438)
- Akshaya Radhakrishnan (ORCID: https://orcid.org/0009-0005-4572-4613)
- Vinayak Uppin
- Daniel Feinberg (ORCID: https://orcid.org/0000-0003-4833-6470)
- Duncan Stearns (ORCID: https://orcid.org/0000-0002-8847-6112)
- Reshmi Parameswaran (ORCID: https://orcid.org/0000-0002-8043-7450)
- Aarshvi Jahnvi Bhatt
- Kayla Klatt (ORCID: https://orcid.org/0000-0002-2119-0152)
Institutions
- Cleveland Clinic (US)
- Cleveland Clinic Lerner College of Medicine (US)
- Rainbow Babies & Children's Hospital (US)
- University School (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-03-17
- DOI
- https://doi.org/10.1186/s12916-026-04729-8
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Case Western Reserve University
- Case Comprehensive Cancer Center, Case Western Reserve University