Tailoring Ga Flexible Single-Atom Nanozymes for Self-Adaptive Catalytic Performance through Multienzyme Activity Switching
Inorganic nanozymes remain limited by rigid active-center structures, lacking the adaptive flexibility of natural enzymes. Here we report a flexible single-atom nanozyme (FSAzyme) enabled by regulation of Ga coordination. A dynamically reconstructing Ga-N<sub>3</sub>S site exhibits self-adaptive electronic modulation, allowing the FSAzyme to realize multiple enzyme-mimicking activities and versatile sensing functions. These results establish a general design strategy to introduce enzyme-like adaptivity into single-atom nanozymes.
Authors
- Jiarui Yang (ORCID: https://orcid.org/0000-0001-8238-7699)
- Zedong Zhang (ORCID: https://orcid.org/0009-0003-9312-8387)
- Dingsheng S. Wang (ORCID: https://orcid.org/0000-0003-0074-7633)
- Jian Shen (ORCID: https://orcid.org/0000-0002-9009-6151)
- Wenming Sun (ORCID: https://orcid.org/0000-0002-7832-6284)
- Daping He
- D. Zhang
- Zechao Zhuang
- Xiangwen Liu
- Guangchun Song
Institutions
- Wuhan University of Technology (CN)
- Institute of Food Science and Technology (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Ministry of Agriculture and Rural Affairs (CN)
- Beijing Academy of Science and Technology (CN)
- Capital Normal University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1021/jacs.5c23161
- Primary Topic
- Advanced Nanomaterials in Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00