Polygenic Contribution to Sensorineural Hearing Loss Implicates Novel Risk Loci and Convergence with Congenital Hearing Loss Genes
In this multi-ancestry GWAS, we identify 108 loci with 54 novel genes. Despite the enrichment of CHL genes, 97% of the risk for adult-onset SNHL is captured by SNPs outside of monogenic hearing loss genes. Although SNHL in the UKB and MVP were assessed using different phenotypes, genetic signals between the two cohorts are predominantly shared, and locus discovery is boosted through increased sample size in meta-analysis.
Authors
- Adam X. Maihofer (ORCID: https://orcid.org/0000-0003-4517-1623)
- Elizabeth A. Mikita (ORCID: https://orcid.org/0000-0002-2113-8274)
- Caroline E. Mackey
- Allen F. Ryan
- Jacquelyn A. Johnson
- Caroline M. Nievergelt
- Royce E. Clifford
Institutions
- UC San Diego Health System (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
Publication Details
- Journal
- Journal of the Association for Research in Otolaryngology
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1007/s10162-026-01044-0
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Veterans Affairs
- Office of Research and Development