A REVIEW ON FAST DISSOLVING DRUG DELIVERY SYSTEM

Fast Dissolving Drug Delivery Systems (FDDDS) signify a remarkable innovation in pharmaceutical technology, promoting improved patient compliance and a rapid onset of therapeutic effects. These systems are designed to disintegrate or dissolve rapidly in the oral cavity without the need for water, making them especially appropriate for pediatric, geriatric, and dysphagic patients. FDDDS encompass various dosage forms, including fast dissolving tablets, oral disintegrating films, and lyophilized wafers, which are developed using super disintegrants, taste-masking agents, and advanced manufacturing techniques such as direct compression, lyophilization, and 3D printing. The primary advantage of these systems lies in their ability to enhance bioavailability and bypass first-pass metabolism in certain cases. However, challenges persist, including mechanical strength, moisture sensitivity, and limited drug loading capacity. This review provides a comprehensive analysis of the formulation strategies, mechanisms, evaluation criteria, and recent advancements in FDDDS. It also highlights marketed products and future prospects, emphasizing the growing significance of these systems in improving therapeutic outcomes and patient-centered drug delivery.