Inhaled Antibiotics to Treat Ventilator-Associated Pneumonia: A Systematic Review and Meta-Analysis
Compared with placebo/blank, adjunctive inhaled antibiotics improve clinical cure and microbiological eradication, and may reduce mortality, particularly in VAP-only patients. Exploratory analyses based on limited data suggest potential advantages over IV therapy, including shorter ventilator duration and lower nephrotoxicity, warranting further high-quality trials.
Authors
- Shan Lyu (ORCID: https://orcid.org/0000-0003-4219-2920)
- Jie Li (ORCID: https://orcid.org/0000-0003-0973-8645)
- Xiaojing Qin
- Stephan Ehrmann
- Jian Luo
- Guoqiang Jing
- Wanjia He
- Ping Liu
Institutions
- Université de Tours (FR)
- Department of Health (CN)
- Shandong University of Aeronautics (CN)
- Inserm (FR)
- Sun Yat-sen University (CN)
- Peking University (CN)
- Centre Hospitalier Universitaire de Tours (FR)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Clinical Investigation Center Plurithematic Tours (FR)
- Peking University People's Hospital (CN)
- Oxford BioMedica (United Kingdom) (GB)
- French Clinical Research Infrastructure Network (FR)
- Rush University (US)
- University of Hong Kong (HK)
Publication Details
- Journal
- Critical Care Medicine
- Published
- 2026-03-16
- DOI
- https://doi.org/10.1097/ccm.0000000000007072
- Citations
- 1
- Primary Topic
- Nosocomial Infections in ICU
- Type
- article
- Field-Weighted Citation Impact
- 40.09