Silver/Indium-Catalyzed Cyclization of <i>O</i> -Alkynylisocyanobenzenes with Nitriles for the Synthesis of Amide-Substituted Quinolines

An efficient method for the synthesis of amide-substituted quinolines through silver/indium-catalyzed cyclization from <i>o</i>-alkynylisocyanobenzenes with nitriles has been reported. The reaction was initiated by the intramolecular cyclization of the <i>o</i>-alkynylisocyanobenzenes to generate the quinolyl cationic intermediate, followed by an intermolecular Ritter reaction with nitriles to give a nitrile-quinoline-based nitrilium salt, subsequently with hydrolysis to afford the amide-substituted quinolines.