Gene-environment equivalence:The fundamental principle of Mendelian randomization

The explosion of Mendelian Randomization (MR) submissions of dubious quality to journals globally is well recognized. Contributing to this deluge of publications may be the poor understanding among practitioners, reviewers and editors of gene-environment equivalence, the fundamental principle of MR.

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Journal
Bristol Research (University of Bristol)
Published
2026-03-13
Primary Topic
Genetic Associations and Epidemiology
Type
article
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article

Gene-environment equivalence:The fundamental principle of Mendelian randomization

George Davey Smith, Shah Ebrahim, Gibran Hemani
Bristol Research (University of Bristol)
Genetic Associations and Epidemiology
article

Gene-environment equivalence:The fundamental principle of Mendelian randomization

George Davey Smith, Shah Ebrahim, Gibran Hemani
article en

Abstract

The explosion of Mendelian Randomization (MR) submissions of dubious quality to journals globally is well recognized. Contributing to this deluge of publications may be the poor understanding among practitioners, reviewers and editors of gene-environment equivalence, the fundamental principle of MR.

Bristol Research (University of Bristol)
London School of Hygiene & Tropical Medicine (GB), MRC Epidemiology Unit (GB), MRC Integrative Epidemiology Unit
No poverty
Openalex Percentile: Top 22%
Genetic Associations and Epidemiology
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