Heterogeneous associations of regional adipose depots with liver fibrosis in U.S. adults
Regional fat distribution exhibits heterogeneous associations with liver fibrosis. Thigh subcutaneous fat shows an inverse association with fibrosis that persists after adjustment for overall adiposity (BMI), whereas abdominal fat depots do not. These findings highlight fat distribution as a clinically relevant dimension beyond total adiposity for refining fibrosis risk stratification in MASLD.
Authors
- Tsung‐Po Chen (ORCID: https://orcid.org/0000-0002-8016-2573)
- Wen-Jen Lin
- Ci Wang (ORCID: https://orcid.org/0009-0007-8227-381X)
- Hsian-Han Kao
- Kuan-Yu Lai
Institutions
- China Medical University (TW)
- China Medical University Hospital (TW)
Publication Details
- Journal
- Metabolism Open
- Published
- 2026-03-15
- DOI
- https://doi.org/10.1016/j.metop.2026.100461
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00