High dietary fiber is associated with improved outcomes in patients with melanoma and sarcoma treated with immunotherapy regardless of gut microbiome dysbiosis and social vulnerability
Increased social vulnerability was associated with a less favorable gut microbiome composition but not worse OS among melanoma and sarcoma patients treated with ICB. Consistent with prior findings, high dietary fiber intake emerged as a potentially modifiable pathway to improve outcomes in patients initiating ICB, particularly those with increased SVI.
Authors
- Brittany C. Fields (ORCID: https://orcid.org/0000-0003-1424-6004)
- Raymond Traweek
- Jennifer Ann Wargo (ORCID: https://orcid.org/0000-0003-3438-7576)
- Manoj Chelvanambi (ORCID: https://orcid.org/0000-0003-2130-3118)
- Russell Gardner Witt (ORCID: https://orcid.org/0000-0003-3747-8633)
- Ashish Damania (ORCID: https://orcid.org/0009-0001-3158-2846)
- Kai Jiang (ORCID: https://orcid.org/0000-0001-9795-9290)
- Emily Z. Keung (ORCID: https://orcid.org/0000-0002-8783-8484)
- Christina Lynn Roland (ORCID: https://orcid.org/0000-0003-3400-0087)
- Yi‐Ju Jill Chiang
- Carrie Daniel
- A. T. Holder (ORCID: https://orcid.org/0009-0002-3882-7073)
- Nadim Ajami
- Xiaotao Zhang
- Elise Nassif‐Haddad
- Christine B. Peterson
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- The University of Texas Health Science Center at Houston (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Cancer
- Published
- 2026-03-15
- DOI
- https://doi.org/10.1002/cncr.70335
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00