Integrating 1H NMR-Based Fecal Metabolomics with Gut Microbiota-Metabolite Correlation Analysis and Network Pharmacology to Explore Anti-Hyperlipidemic Mechanisms of Red Clover in High-Fat Diet-Induced Mice
RC exerts anti-hyperlipidemic effects through a dual mechanism involving modulation of the gut microbiota and direct targeting of TNF and EGFR by its in vivo metabolites. This synergistic interplay underscores the potential of RC as a holistic therapeutic agent for HLP, targeting both microbial and molecular pathways.
Authors
- Zili Guo (ORCID: https://orcid.org/0000-0003-1885-7646)
- Sheng Fang
- Yi Liu (ORCID: https://orcid.org/0000-0002-1058-0382)
- Jinping Gu (ORCID: https://orcid.org/0009-0002-6143-8957)
- Xianrui Liang
- Luoyi Shen
- Jiani Xiang
Institutions
- Ministry of Education (NZ)
- Zhejiang Shuren University (CN)
- Zhejiang University of Technology (CN)
- Zhejiang Gongshang University (CN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2026-03-13
- DOI
- https://doi.org/10.2174/0109298673406549251205092334
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00