Association Between Cholinesterase Inhibitor‐Overactive Bladder Antimuscarinic Prescribing Cascade and Risk of Delirium and Falls Among Individuals Living With Dementia

In older adults living with dementia, the estimated association between initiation of OAB antimuscarinics following ChEIs and the risks of delirium or falls, compared with mirabegron, was statistically compatible with benefit, harm, or no clinically meaningful difference. These findings highlight the need to evaluate whether OAB antimuscarinics are prescribed in response to true clinical need or as part of a prescribing cascade. Given the limited number of outcome events and resulting wide 95% CIs, future studies are needed to more precisely estimate the risk.

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Publication Details

Journal
Journal of the American Geriatrics Society
Published
2026-03-15
DOI
https://doi.org/10.1111/jgs.70386
Primary Topic
Urinary Bladder and Prostate Research
Type
article
Field-Weighted Citation Impact
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article

Association Between Cholinesterase Inhibitor‐Overactive Bladder Antimuscarinic Prescribing Cascade and Risk of Delirium and Falls Among Individuals Living With Dementia

Ibraheem M. Karaye, Ismaeel U. Yunusa, Sarah Beth Tucker, Saud Alsahali et al.
Journal of the American Geriatrics Society
Urinary Bladder and Prostate Research
article

Association Between Cholinesterase Inhibitor‐Overactive Bladder Antimuscarinic Prescribing Cascade and Risk of Delirium and Falls Among Individuals Living With Dementia

Ibraheem M. Karaye, Ismaeel U. Yunusa, Sarah Beth Tucker, Saud Alsahali, Jingkai Wei, Chengwen Teng, Chijioke M. Okeke, Erin D. Zwick, Bryan L. Love, Krithika Rajagopalan
article en

Abstract

In older adults living with dementia, the estimated association between initiation of OAB antimuscarinics following ChEIs and the risks of delirium or falls, compared with mirabegron, was statistically compatible with benefit, harm, or no clinically meaningful difference. These findings highlight the need to evaluate whether OAB antimuscarinics are prescribed in response to true clinical need or as part of a prescribing cascade. Given the limited number of outcome events and resulting wide 95% CIs, future studies are needed to more precisely estimate the risk.

Journal of the American Geriatrics Society
Albert Einstein College of Medicine (US), Montefiore Medical Center (US), Hofstra University (US), University of South Carolina (US), Qassim University (SA), American Society for Neurochemistry (US), The University of Texas Health Science Center (US), University of Houston (US), The University of Texas Health Science Center at Houston (US)
Openalex Percentile: Top 20%
Urinary Bladder and Prostate Research
DOIOpen Access PDFOpenAlex
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