Topical Emulgels: A Hybrid System for Improved Dermal and Transdermal Drug Delivery

The goal of this study was to formulate an emulgel formulation for topical administration that would prevent hepatic first-pass metabolism, increase emulsion stability, lower dosage requirements, and increase residence time. An emulgel is a hybrid dosage form that combines the properties of both emulsions and gels, which are particularly significant for the delivery of hydrophobic substances; it enhances drug penetration through the epidermal barrier and promotes effective skin diffusion (especially for medications with low water solubility). This article looks at the advantages, choice of components, preparation methods, development, and characterization of emulgel in drug delivery, all of which are based on the latest research. The pH, viscosity, particle size, zeta potential, drug content, stability study, skin irritation test, and other properties of the prepared formulation are evaluated. Keywords: Emulgel, hybrid dosage form, hydrophobic substances, future aspect