Landscape of somatic genetic alterations and PAM50 intrinsic subtypes in breast cancer associated with germline pathogenic variants in DNA-repair genes
GPVs in BRCA1, BRCA2, ATM, CHEK2, and PALB2 are associated with distinct intrinsic breast cancer subtypes and somatic genomic alterations. These findings may enhance precision in risk stratification and guide personalized treatment strategies.
Authors
- Anne Weidner (ORCID: https://orcid.org/0000-0002-8007-8734)
- Binyam Yilma (ORCID: https://orcid.org/0009-0007-8845-5390)
- Padma Sheila Rajagopal (ORCID: https://orcid.org/0000-0002-0489-0819)
- Ali T. Arafa
- Emily A. Teslow (ORCID: https://orcid.org/0000-0001-5506-1749)
- Jennifer G. Whisenant (ORCID: https://orcid.org/0000-0002-3435-2464)
- Siddhartha Yadav (ORCID: https://orcid.org/0000-0003-4630-9903)
- Minxuan Huang (ORCID: https://orcid.org/0000-0001-5551-586X)
- Tuya Pal
- Stamatina Fragkogianni
- Sonya Reid
- Elizabeth Mauer
- Emmanuel S Antonarakis
- Calvin Chao
- Allison Kurian
- Fergus J Couch
Institutions
- Mayo Clinic (US)
- Tempus Labs (United States) (US)
- Mayo Clinic in Arizona (US)
- University of Minnesota Medical Center (US)
- National Cancer Institute (US)
- Mayo Clinic in Florida (US)
- Vanderbilt University Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2026-03-11
- DOI
- https://doi.org/10.1093/jnci/djag070
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00