UBE2M Identified by CRISPR Screening as a Key Regulator of Cisplatin-Induced Acute Kidney Injury <i>via</i> the p53 Pathway

UBE2M could serve as a novel therapeutic target for the prevention and treatment of cisplatin-induced nephrotoxicity.

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Publication Details

Journal
Endocrine Metabolic & Immune Disorders - Drug Targets
Published
2026-03-12
DOI
https://doi.org/10.2174/0118715303410982251112055248
Primary Topic
Chemotherapy-induced organ toxicity mitigation
Type
article
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article

UBE2M Identified by CRISPR Screening as a Key Regulator of Cisplatin-Induced Acute Kidney Injury via the p53 Pathway

Xijie Gao, Danqin Lu, Lihua Ni, C. Y. Yuan et al.
Endocrine Metabolic & Immune Disorders - Drug Targets
Chemotherapy-induced organ toxicity mitigation
article

UBE2M Identified by CRISPR Screening as a Key Regulator of Cisplatin-Induced Acute Kidney Injury via the p53 Pathway

Xijie Gao, Danqin Lu, Lihua Ni, C. Y. Yuan, Y. Wu, Ayinigaer Yusufu, Feng Chen
article en

Abstract

UBE2M could serve as a novel therapeutic target for the prevention and treatment of cisplatin-induced nephrotoxicity.

Endocrine Metabolic & Immune Disorders - Drug TargetsVol. 26
China Three Gorges University (CN), Wuhan University (CN), Zhongnan Hospital of Wuhan University (CN), Jingzhou Central Hospital (CN), Yichang Central People's Hospital (CN)
Good health and well-being
Openalex Percentile: Top 22%
Chemotherapy-induced organ toxicity mitigation
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