The hippo-YAP1/TEAD1-SLC7A5 axis: uncovering a novel therapeutic target for oxalate-induced renal tubular ferroptosis
We establish the Hippo-YAP1/TEAD1-SLC7A5 axis as a master regulatory pathway controlling oxalate-induced ferroptosis. This pathway represents a promising therapeutic target for oxalate nephropathy and provides fundamental insights into stress-responsive ferroptosis regulation in kidney disease.
Authors
- Wu Wan
- Bang Wang (ORCID: https://orcid.org/0000-0002-0312-4805)
- Junyi Yang
- Zhilong Ma
- Xiaoyan Yu (ORCID: https://orcid.org/0000-0002-0748-3522)
- Jiabo Li
- Guoruiyu Lyu
- Dongfeng Yuan
- Yongqi Wang
- Yang Xun
Institutions
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Redox Report
- Published
- 2026-03-15
- DOI
- https://doi.org/10.1080/13510002.2026.2643967
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00