Aloe Polysaccharides against 3-Nitropropionic acid-induced Huntington’s disease-like symptoms: Role of BDNF/NF-κB/Nrf2 signaling pathways
These findings reveal that APs promote neuroprotection not only by modulating oxidative stress, neuroinflammation, neurotransmission, and apoptosis, but also by specifically upregulating genes in the mitochondrial biogenesis pathway, highlighting their potential as a natural therapeutic candidate for HD management.
Authors
- Mohammad Ashfak Habib (ORCID: https://orcid.org/0000-0002-4140-0970)
- Omar Awad Alsaidan (ORCID: https://orcid.org/0000-0002-2848-2932)
- Sami I. Alzarea (ORCID: https://orcid.org/0000-0003-4007-4023)
- Nadeem Sayyed (ORCID: https://orcid.org/0000-0003-0517-4934)
- Imran Kazmi (ORCID: https://orcid.org/0000-0003-1881-5219)
- Samy A. Abusikkien
- Hadeel A. Alsufyani
- Muhammad Afzal
- Misbahuddin Rafeeq
Institutions
- Ain Shams University (EG)
- King Abdulaziz University (SA)
- Jouf University (SA)
- Dhofar University (OM)
- Instytut Farmaceutyczny (PL)
- Batterjee Medical College
Publication Details
- Journal
- Current Neuropharmacology
- Published
- 2026-03-13
- DOI
- https://doi.org/10.2174/011570159x422437251223062825
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00