NETosis-derived PADs mediate Citrullination of Oral Bacteria to promote Inflammation in Rheumatoid Arthritis
Our data support the hypothesis that in RA patients with PD, citrullinated oral bacteria breach damaged periodontal tissue to enter the circulation and induce both innate and adaptive proinflammatory responses that promote synovial tissue destruction.
Authors
- William H. Robinson (ORCID: https://orcid.org/0000-0003-4385-704X)
- Mahesh Pandit (ORCID: https://orcid.org/0009-0007-9111-444X)
- D. Orange
- Alejandro M. Gomez (ORCID: https://orcid.org/0000-0003-4415-2615)
- Zelda Z. Love (ORCID: https://orcid.org/0000-0002-2478-7720)
- Orr Sharpe (ORCID: https://orcid.org/0000-0003-1986-7555)
- M Howard
- Shaghayegh Jahanbani (ORCID: https://orcid.org/0000-0001-7789-4856)
- Shady Younis (ORCID: https://orcid.org/0000-0002-4319-1738)
- Suman Acharya
- Camille Brewer
Institutions
- Hospital for Special Surgery (US)
- VA Palo Alto Health Care System (US)
- Rockefeller University Hospital (US)
Publication Details
- Journal
- The Journal of Rheumatology
- Published
- 2026-03-15
- DOI
- https://doi.org/10.3899/jrheum.2025-0792
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00