The Role of Phytosomes in Enhancing the Bioavailability and Efficacy of Herbal Phytoconstituents with Anxiolytic Potential - A Comprehensive Review

Anxiety disorders are among the most common mental health illnesses in the world, impacting millions of people from a wide range of backgrounds. Herbal anxiolytics have gained significant attention as natural therapeutic alternatives. However, many of these botanical extracts exhibit poor bioavailability, limiting their therapeutic efficacy. Phytosome technology has appeared as a cutting-edge method of drug delivery intended to improve the bioavailability and efficacy of herbal compounds. This review comprehensively explores the potential of phytosomes to improve the pharmacokinetics and bioavailability of anxiolytic herbs, focusing on their formulation strategies, delivery advantages, and the prospects for their application in anxiety management. While a substantial body of studies has examined the development and formulation of phytosomes for various therapeutic applications, few have specifically evaluated their anxiolytic properties. Additionally, this paper examines safety considerations, regulatory aspects, and future research directions essential for optimizing phytosome-based anxiolytic interventions. By bridging traditional herbal medicine with advanced drug delivery systems, phytosomes present a transformative strategy to enhance the therapeutic bioavailability and efficacy of herbal-based treatments for anxiety disorders.