Social defeat stress responses in the stress alternative model are dependent on sex and anterior basolateral amygdala orexin 2 receptors

Female and male mice exposed to social stress exhibit distinct behavioral adaptations, but similarly, separate into resilient and susceptible subpopulations. Inhibiting Orx<sub>2</sub>R promotes stress-vulnerable behavior in females, and modifies transcription in BLA microcircuits, suggesting a role for Orx<sub>2</sub>R defining stress behavior.

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Publication Details

Journal
Biology of Sex Differences
Published
2026-03-15
DOI
https://doi.org/10.1186/s13293-026-00858-0
Primary Topic
Sleep and Wakefulness Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Social defeat stress responses in the stress alternative model are dependent on sex and anterior basolateral amygdala orexin 2 receptors

Cliff H. Summers, Linda Meyer, Wayne J. Korzan, Leighton J. Ledesma et al.
Biology of Sex Differences
Sleep and Wakefulness Research
article

Social defeat stress responses in the stress alternative model are dependent on sex and anterior basolateral amygdala orexin 2 receptors

Cliff H. Summers, Linda Meyer, Wayne J. Korzan, Leighton J. Ledesma, Trent L. Greschke, Renée A Brummels, Jazmine D.W. Yaeger, R. Parrish Waters, Megan M. John, J. J. Gale
article en

Abstract

Female and male mice exposed to social stress exhibit distinct behavioral adaptations, but similarly, separate into resilient and susceptible subpopulations. Inhibiting Orx<sub>2</sub>R promotes stress-vulnerable behavior in females, and modifies transcription in BLA microcircuits, suggesting a role for Orx<sub>2</sub>R defining stress behavior.

Biology of Sex Differences
University of South Dakota (US), University of Mary Washington (US), Medical College of Wisconsin (US), Sanford Research (US), Sioux Falls VA Health Care System (US), University of West Alabama (US)
Reduced inequalities
Openalex Percentile: Top 25%
Sleep and Wakefulness Research
DOIOpen Access PDFOpenAlex
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