A NIR-Ⅱ-Immunostimulatory nanoplatform rewires immunometabolism to unleash STING-driven antitumor immunity
Our study illustrates that the IRM nanoplatform effectively merges multimodal imaging with immunometabolic modulation, establishing a durable and systemic antitumor immunity. This work offers a translatable strategy for combinational photo-immunotherapy against advanced melanoma.
Authors
- Maolin Chen (ORCID: https://orcid.org/0000-0002-0806-4223)
- Tong Xia (ORCID: https://orcid.org/0000-0001-7136-8361)
- Changzhen Sun (ORCID: https://orcid.org/0000-0002-5949-2244)
- Xun Yang
- Hongye Liao
- Simei Yang
- Xuefeng Chen
- Li Liu
- Gaoyang Shen
- Ya Wu
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-03-15
- DOI
- https://doi.org/10.1186/s12951-026-04162-2
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00