Therapeutic potential of Corydalis alkaloids in polycystic ovary syndrome: In silico and preliminary In vitro Insights into ESR1 and SRC-associated pathways
C. bungeana Turcz. and C. decumbens (Thunb.) Pers. possess a range of bioactive compounds with potential therapeutic effects on PCOS. The network pharmacology approach unveiled the multi-faceted interactions of these compounds with PCOS-related biological pathways, providing a foundation for the development of novel, multi-targeted therapeutic strategies for PCOS. Further experimental and clinical validation is required to translate these findings into tangible clinical benefits.
Authors
- Dawood Ahmad Warraich
- Yuxuan Meng (ORCID: https://orcid.org/0009-0009-4287-5861)
- Israr Fatima (ORCID: https://orcid.org/0009-0009-3630-8764)
- Hafeez Ur Rehman (ORCID: https://orcid.org/0000-0002-1386-5287)
- Mohamed Aldaw
- Mingzhi Liao
- Abdur Rehman
Institutions
- North West Agriculture and Forestry University (CN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2026-03-13
- DOI
- https://doi.org/10.2174/0109298673413062251204121042
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00