The Psoriatic Metabolic March: Reframing Immunometabolic Progression in Psoriatic Disease

The concept of the "psoriatic march," proposed more than a decade ago by Boehncke et al, provided a valuable framework to explain how chronic cutaneous inflammation could lead to systemic metabolic dysfunction, endothelial injury, and ultimately, cardiovascular disease.¹ This model, which focuses on downstream vascular biology driven by persistent Th1/Th17 activation, has been deeply influential and continues to shape clinical reasoning.