MonoHER selectively enhances the radiotherapy response in p53 wild-type breast cancer via stabilization of p53
MonoHER modestly sensitize only p53-proficient breast cancer cells to radiation by stabilizing and activating p53, highlighting its potential as an adjuvant radiosensitizer.
Authors
- Ludwig J. Dubois (ORCID: https://orcid.org/0000-0002-8887-4137)
- Chujie Li (ORCID: https://orcid.org/0000-0002-3362-072X)
- Rianne Biemans
- Xiaojun Li
- Ming Zhang
Institutions
- Hainan University (CN)
- University of Manchester (GB)
- Maastricht University (NL)
- St Mary's Hospital (GB)
- Zhongshan Hospital (CN)
- Maastro Clinic (NL)
Publication Details
- Journal
- Clinical and Translational Radiation Oncology
- Published
- 2026-03-15
- DOI
- https://doi.org/10.1016/j.ctro.2026.101147
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Scholarship Council