Antisense Molecules: Design, Chemistry, and Therapeutic Innovations
Antisense oligonucleotides (ASOs) have been successfully approved by the FDA for the development of drugs such as Nusinersen (used for the treatment of spinal muscular atrophy) and Fomivirsen (used for treating Cytomegalovirus retinitis). ASOs offer a unique ability to target specific RNA sequences and help overcome limitations associated with traditional therapies.
Authors
- Abitha Sri Ganapathy
- Swetha Aravamudhan
- Suryalakshmi Guhanathan
- Jocelyn Olivia Prabhakar David
- Prema Vediappan
Institutions
- Tamil Nadu Dr. M.G.R. Medical University (IN)
Publication Details
- Journal
- Mini-Reviews in Medicinal Chemistry
- Published
- 2026-03-13
- DOI
- https://doi.org/10.2174/0113895575428832251206055438
- Primary Topic
- Neurogenetic and Muscular Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00