Early apoptosis predicts orthodontically induced root resorption: inhibitory effects of lithium in a rat model
Early PDL compression and apoptosis play pivotal roles in OIRR initiation and are potential predictive markers. Lithium attenuated OIRR by suppressing early apoptosis without altering PDL compression, highlighting early apoptosis as a promising therapeutic target for OIRR prevention.
Authors
- Yuka Hotokezaka
- Hitoshi Hotokezaka
- Yukiko Morita (ORCID: https://orcid.org/0000-0002-6117-777X)
- Kie Nishioka-Sakamoto
- Yukako Nashiro-Oyakawa
- Mariko Funaki-Dohi
- Mizuki Ohama
- Yosuke Iuchi
- Takuya Nakamura
- Noriaki Yoshida
Institutions
- Nagasaki University (JP)
Publication Details
- Journal
- The Angle Orthodontist
- Published
- 2026-03-16
- DOI
- https://doi.org/10.2319/082825-731.1
- Primary Topic
- Orthodontics and Dentofacial Orthopedics
- Type
- article
- Field-Weighted Citation Impact
- 0.00