A  Comprehensive Review on Fast Dissolving Tablets

The oral route is the most preferred route of administration due to its low cost, ease of administration, and patient compliance. Pharmaceutical technologists introduced the novel dosage forms known as oral disintegrating tablet (ODT), fast disintegrating tablet (FDT), and mouth dissolving tablet (MDT). According to the United States Food and Drug Administration (FDA), it is defined as a solid dosage form containing a medicinal substance or medicament that disintegrates rapidly, usually within a matter of seconds, when placed upon the tongue. FDT tablets dissolve quickly in saliva, without requiring water. Recently FDTs have been the most popular and effective dosage form. It is used as an alternative to conventional dosage forms for elderly and pediatric patients. Fast-dissolving tablets improve patient compliance and quicker onset of action. Superdisintegrants play an important role in the formulation of fast-dissolving tablets that increase the tablet disintegration in the buccal cavity. This review describes the various technologies used to develop the fast-dissolving tablet. This review describes the technologies of sublimation, molding, spray drying, melting the granulation, and the cotton candy process. This review also describes the advantages, disadvantages, challenges, salient features of FDT, and evaluation of various evaluation parameters of FDT. Keywords: FDTs, FDA, Fast-dissolving tablet, Superdisintegrants