Integrated Network Pharmacology and Molecular Modeling Reveal Therapeutic Potential of Silybum marianum Compounds against NAFLD
This integrative study provides a mechanistic basis for the anti-NAFLD activity of Silybum marianum, identifying silybin A and silandrin as promising scaffolds for AKT1 and MTOR-targeted therapy.
Authors
- Ling Guo (ORCID: https://orcid.org/0000-0003-1118-6798)
- Dong Cai (ORCID: https://orcid.org/0000-0002-9559-1506)
- He Wang
- Jiqi Li
- Yutong Li
- Yuedi Ni
- Lianshan Chen
Institutions
- Jinzhou Medical University (CN)
Publication Details
- Journal
- Current Pharmaceutical Design
- Published
- 2026-03-13
- DOI
- https://doi.org/10.2174/0113816128428323251127043544
- Primary Topic
- Silymarin and Mushroom Poisoning
- Type
- article
- Field-Weighted Citation Impact
- 0.00