A breakthrough invasive Aspergillus granulosus infection following azole antifungal therapy in a patient with primary myelofibrosis: case report

Invasive aspergillosis (IA) primarily affects immunocompromised patients, with <i>Aspergillus granulosus</i> being a rare cause. Most cases occur in transplant recipients, and breakthrough infections may develop after azole therapy due to cryptic species and antifungal resistance. Here, we present the first non-transplant case of breakthrough <i>A. granulosus</i> infection following azole therapy with a fatal outcome. This case highlights the importance of early diagnosis, accurate species identification, and appropriate antifungal treatment for breakthrough invasive fungal infections.