Dysplasia in sessile serrated lesions: frequency, interobserver variability and added value of immunohistochemistry
The diagnosis of SSLd appears to have good reproducibility among pathologists and positive diagnostic trends that are observed in recent years. MLH1 is the only IHC marker with robust clinical utility to identify SSLd that do not meet the morphologic criteria for overt dysplasia but should be used only in selected cases due to its low prevalence.
Authors
- Valentina Angerilli (ORCID: https://orcid.org/0000-0002-9799-9257)
- Matteo Fassan (ORCID: https://orcid.org/0000-0001-6515-5482)
- Gesina van Lijnschoten
- Nicole C.T. van Grieken (ORCID: https://orcid.org/0000-0001-9992-0760)
- Nanette S van Roermund
- M. Elisa Vink‐Börger
- Chantal C.H.J. Kuijpers
- Joep E. Ijspeert
- Rachel S. van der Post
- Iris D. Nagtegaal
Institutions
- University of Padua (IT)
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- The Netherlands Cancer Institute (NL)
- AULSS 2 Marca Trevigiana (IT)
- Eurofins (Netherlands) (NL)
- Istituto Oncologico Veneto (IT)
- Radboud Institute for Molecular Life Sciences (NL)
- PAMM (NL)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
- Nationwide Mutual Insurance Company (United States) (US)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Histopathology
- Published
- 2026-03-14
- DOI
- https://doi.org/10.1111/his.70135
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00