Multi-omics Mendelian randomization prioritizes BMP6 as a candidate therapeutic target in intervertebral disc degeneration

We prioritized BMP6 as a candidate therapeutic target for IVDD and identified circulating urate as a potential mediator based on a suggestive mediation signal. These findings offer new mechanistic insights into the potential relationship between BMP6, urate metabolism, and IVDD. This gene and its associated metabolite represent promising targets for IVDD intervention and may inform subsequent translational research and preclinical validation.