Genomic sequencing of multicystic mesothelioma finds cohesin complex mutations associated with disease recurrence in patients referred for cytoreductive surgery and HIPEC
We see recurrent somatic mutations in MCMs particularly at a novel mutational hotspot in SMC3, consistent with a neoplastic process. Mutations in cohesin complex genes are associated with disease recurrence.
Authors
- Sarah Ennis (ORCID: https://orcid.org/0000-0003-2648-0869)
- Alex H. Mirnezami
- Manuel Galguera Domínguez
- Amatta Mirandari (ORCID: https://orcid.org/0000-0002-3454-8723)
- Reuben J. Pengelly (ORCID: https://orcid.org/0000-0001-7022-645X)
- Jonathan W. Essex (ORCID: https://orcid.org/0000-0003-2639-2746)
- Alexios Tzivanakis (ORCID: https://orcid.org/0000-0003-0128-0350)
- Sophia Stanford (ORCID: https://orcid.org/0000-0002-7855-1991)
- Sanjeev Dayal (ORCID: https://orcid.org/0000-0002-6571-5344)
- Norman J. Carr
- Faheez Mohamed
- Brendan John Moran
- Jane Gibson
- Konstantinos Boukas
- Kevin Hocking
- Thomas Desmond Cecil
- Steven Turner
- Gbadebo Adeleke
Institutions
- Salisbury District Hospital (GB)
- Southampton General Hospital (GB)
- Basingstoke and North Hampshire Hospital (GB)
- University of Southampton (GB)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2026-03-14
- DOI
- https://doi.org/10.1038/s41416-026-03366-5
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Southampton
- Pelican Cancer Foundation
- Engineering and Physical Sciences Research Council