Cephalosporins Versus Non-cephalosporin Antibiotics for Perioperative Prophylaxis in Primary Arthroplasty: A Systematic Review and Meta-Analysis
Cephalosporins, particularly cefazolin or cefuroxime, remain the preferred prophylactic agents for primary arthroplasty. This quantitative synthesis reinforces their protective association against prosthetic joint infection and supports adherence to guideline-endorsed prophylaxis.
Authors
- Aaron Joseph Tande (ORCID: https://orcid.org/0000-0001-9775-7082)
- Fabio Borgonovo (ORCID: https://orcid.org/0000-0001-5796-671X)
- Rita Igwilo-Alaneme
- Said El Zein (ORCID: https://orcid.org/0000-0003-4331-5259)
- Jack McHugh (ORCID: https://orcid.org/0000-0002-7507-232X)
- Vasupriya Ravi (ORCID: https://orcid.org/0009-0006-2063-6235)
- Francesco Petri
- Elie Berbari
- M Hassan Murad
- Takahiro Matsuo
Institutions
- Mayo Clinic (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- ASST Fatebenefratelli Sacco (IT)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2026-03-12
- DOI
- https://doi.org/10.1093/cid/ciag172
- Primary Topic
- Surgical site infection prevention
- Type
- article
- Field-Weighted Citation Impact
- 0.00