Exploring the Mechanism of Selenium-Biofortified PolygonatumKingianum in Alzheimer's Disease: An Integrated Metabolomics andNetwork Pharmacology In Silico Study
This study establishes a predictive "metabolomics-network pharmacology- dynamics" framework for elucidating the multi-target mechanisms of Se-PK against AD. While providing a methodological paradigm for natural product research, these in silico findings prioritize candidate compounds and pathways for future experimental validation, advancing precision phytotherapy in neurodegeneration.
Authors
- Guangdi Shi
- Xiuzhi Wang
- Zixuan Jia
- Qiang Xiao
Institutions
- Minzu University of China (CN)
- Minda Hospital (CN)
- Hubei University (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2026-03-12
- DOI
- https://doi.org/10.2174/0113862073411991251130085435
- Primary Topic
- Selenium in Biological Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00